Sugar-modified Nucleoside Phosphoramidites
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AM Chemicals has designed* a novel family of sugar-modified nucleoside phosphoramidites incorporating a variety of innovative features. The unique design of the sugar-modified nucleoside phosphoramidites ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.
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Product Features
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Specialty nucleoside phosphoramidites (DMT-protected)
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Modified saccharide attached to the phosphoramidites via a triethylene glycol linker
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Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
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Compatible with standard oligonucleotide synthesis protocols
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Requires the standard coupling protocols
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The phosphotriester moieties introduced may require special care and conditions at the deprotection step
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Synthetically feasible for scale-up and manufacturing
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Synthesis of DNA oligos with P=O and P=S backbones
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Synthesis of RNA oligos with P=O and P=S backbones
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* US Patent 10,087,208
US Patent 10,669,301
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Minimum order size (5 g)
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