Non-nucleosidic Modifier Solid Supports for Introducing Functional and Reporter Groups
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AM Chemicals has designed* a novel family of non-nucleosidic solid supports incorporating a variety of innovative features. The unique design of our non-nucleosidic solid supports ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.
Product Features
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Novel, achiral non-nucleosidic building blocks (TMT-protected)
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Amenable for single or multi-labeled oligo synthesis
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Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
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Compatible with standard oligonucleotide synthesis protocols
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Free of structural motifs that lead to undesired side reactions at the deprotection step
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Requires no special treatments or reaction conditions
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Synthetically feasible for scale-up and manufacturing
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Synthesis of DNA oligos with P=O and P=S backbones
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Synthesis of RNA oligos with P=O and P=S backbones
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Numerous phosphoramidites and solid supports:
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Solid phase material – CPG (500 Å, 1000 Å, or 1400 Å), and Polystyrene
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Numerous other ligands are available upon customer’s request
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Scientific publications** on the design, synthesis of non-nucleosidic solid supports and preparation of ligand-oligonucleotides conjugates
** 1. Guzaev, A. P. Oral presentation delivered at XXII International Round Table, Paris, July 2016
2. Gogoi, K., Vvedensky, V., and Guzaev, A.P. Poster presented at TIDES 2017 Conference, San Diego, May 2017 (PDF)
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* US Patent 10,781,175
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Minimum order size (25 g)
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