Non-nucleosidic Modifier Phosphoramidites for Targeted Cellular Uptake of Oligonucleotides
AM Chemicals has designed* a novel family of non-nucleosidic phosphoramidites for efficient, targeted cellular uptake of oligonucleotides. The unique design of our non-nucleosidic phosphoramidites ensures an efficient synthesis (as measured by the purity and yield) of oligonucleotides.
Product Features
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Novel, achiral non-nucleosidic building blocks (TMT-protected)
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Amenable for single or multi-labeled oligo synthesis
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Incorporation of the phosphoramidites at terminal or any desired position of the oligonucleotide
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Compatible with standard oligonucleotide synthesis protocols
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Free of structural motifs that lead to undesired side reactions at the deprotection step
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Requires no special treatments or reaction conditions
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Synthetically feasible for scale-up and manufacturing
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Synthesis of DNA oligos with P=O and P=S backbones
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Synthesis of RNA oligos with P=O and P=S backbones
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Numerous other ligands are available upon customer’s request
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Scientific publications** on the design, synthesis of non-nucleosidic phosphoramidites and preparation of ligand-oligonucleotides conjugates
** 1. Guzaev, A. P. Oral presentation delivered at XXII International Round Table, Paris, July 2016
2. Gogoi, K., Vvedensky, V., and Guzaev, A.P. Poster presented at TIDES 2017 Conference, San Diego, May 2017 (PDF)
* US Patent 10,781,175 and US 11,447,451
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Minimum order quantity (5 g)