in Nucleoside, Nucleotide, and Oligonucleotide Chemistry
Andrei P. Guzaev, Ph.D.
 Publications | Patents

Expertise: Oligonucleotide Synthesis • Oligonucleotide Conjugation Chemistry •
Phosphoramidite Building Blocks • Specialty Solid Supports • Oligonucleotide Process
Improvement and Scale-Up • Nucleoside and Nucleotide Chemistry

Our founder, Dr. Andrei Guzaev also serves as a consultant to the pharmaceutical and allied industries. As
an expert in nucleoside, nucleotide, and oligonucleotide synthesis, he has helped clients solve problems in
their oligonucleotide synthesis facilities with an emphasis on developing or improving reagent base,
processes, and productivity. A graduate of Moscow Institute of Fine Chemical Technology, Russia, he has
over twenty years of diversified academic, industrial, and consulting experience in the oligonucleotide
synthesis.  His experience includes all aspects related to oligonucleotide chemistry, including preparation of
building blocks, process research, optimization, scale-up, synthesis, and purification of complex
oligonucleotides. Prior to founding AM Chemicals LLC, Dr. Guzaev served, for 6 years, as Assistant Director
at the California-based Isis Pharmaceuticals, Inc..  Before that, he held teaching, research, and
management positions at University of Turku, Finland and Institute of Immunology Moscow, Russia.

Projects have included:

  • Expert guidance in selecting the appropriate commercial tools for the preparation of standard,
    modified, and labeled oligonucleotides;
  • Setting up new oligonucleotide synthesis labs from personnel and equipment selection to jump-start of
    the production and on-site personnel training;
  • Productivity improvement for phosphoramidite and oligonucleotide synthesis labs;
  • Troubleshooting all steps of complex oligonucleotide synthesis projects from preparation of building
    blocks to purification of final products;
  • Development of novel reagents for modification of nucleosides, nucleotides, and oligonucleotides;
  • Expert assistance for Attorneys in patent writing;
  • Technical report writing and literature searches

Our mission:

As a California-based organization located in close proximity to San Diego and Los Angeles airports, we
consult nationwide.  We are experienced and proficient in "hands-on" and "on-site" consulting.  We take
pride in being responsive to our clients' needs, staying with a project through completion, and being able to
work on a flexible basis with client personnel or independently.  When a project comes our way, we offer an
initial consultation at no charge to help define the client's needs. As a small and flexible organization, we are
able to respond rapidly and effectively to solve your problems.  We have the expertise and experience to
help, and we look forward to working with you.  To learn more about our services, give us a call or contact
us via e-mail.

AM Chemicals LLC • 4065 Oceanside Blvd, Suite M • Oceanside, CA 92056-5824 • (760) 631-0330
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