Dr. Andrei P. Guzaev
                        
                            
PUBLICATIONS
Guzaev, A. P. Solid-Phase Supports for Oligonucleotide Synthesis. In: Curr. Protoc. Nucleic Acid Chem. Ed.
Beaucage, S. L., Vol. 53, Unit 3.1, pp. 3.1.1-3.1.60, John Wiley & Sons: 2013.
    pdf

Guzaev, A. P. and Pon, R. T. Attachment of Nucleosides and Other Linkers to Solid-Phase Supports for
Oligonucleotide Synthesis.
In: Curr. Protoc. Nucleic Acid Chem. Ed. Beaucage, S. L., Vol. 52, Unit 3.2, pp. 3.2.1-
3.2.23
, John Wiley & Sons: 2013.     pdf

Stiles, D. K.; Zhang, Z.; Ge, P.; Nelson, B.; Grondin, R.; Ai, Y.; Hardy, P.; Nelson, P. T.; Guzaev, A. P.; Butt, M. T.; et
al. Widespread suppression of huntingtin with convection-enhanced delivery of siRNA.
Exp. Neurology 2012, 233,
463-471.     
pdf

Guzaev, A. P. Reactivity of 3H-1,2,4-dithiazole-3-thiones and 3H-1,2-dithiole-3-thiones as sulfurizing agents for
Oligonucleotide Synthesis.
Tetrahedron Lett.  2011, 52, 434-437.     pdf

Kumar, R. K., Guzaev, A. P., Rentel, C., Ravikumar, V. T. Efficient Synthesis of Antisense Phosphorothioate
Oligonucleotides Using a Universal Solid Support.
Tetrahedron 2006, 62, 4528-4534.     pdf

Guzaev, A. P.* and Manoharan, M. A Conformationally Preorganized Universal Solid Support for Efficient
Oligonucleotide Synthesis.
J. Am. Chem. Soc. 2003, 125, 230-231.     pdf

Guzaev, A. P.* and Manoharan, M. Selective Phosphate Protection: a Novel Synthesis of Double-labeled
Oligonucleotides.
Org. Lett. 2001, 3, 3071-3074.     pdf

Guzaev, A. P.;* Bhat, B.; Balow, G.; and Manoharan, M. Synthesis of Chimeric Oligonucleotides Containing
Internucleosidic Phosphodiester and S-pivaloylthioethyl Phosphotriester Residues.
Nucleosides & Nucleotides 2001,
20, 1015-1018.     pdf

Guzaev, A. P.* and Manoharan, M. A Novel Protecting Strategy for Internucleosidic Phosphate and Phosphorothioate
Groups.
Nucleosides & Nucleotides 2001, 20, 1011-1014.     pdf

Doronina, S. O.; Guzaev, A. P.; and Manoharan, M. Efficient Synthesis of Oligonucleotide-Peptide Conjugates on
Large Scale.
Nucleosides & Nucleotides 2001, 20, 1007-1010.     pdf

Guzaev, A. P.* and Manoharan, M. Novel reagents for terminal phosphorylation and thiophosphorylation of synthetic
oligonucleotides.
Tetrahedron Lett. 2001, 42, 4769-4773.     pdf

Guzaev, A. P.* and Manoharan, M. Phosphoramidite Coupling to Oligonucleotides Bearing Unprotected
Internucleosidic Phosphate Moieties.
J. Org. Chem. 2001, 66, 1798-1804.     pdf

Guzaev, A. P.* and Manoharan, M. 2-Benzamidoethyl Group – a Novel Type of Phosphate Protecting Group for
Oligodeoxynucleotide Synthesis.
J. Am. Chem. Soc. 2001, 123, 783-793.     pdf

Guzaev, A. P.* and Manoharan, M. A Novel Phosphate Protection for Oligonucleotide Synthesis: the 2-[(1-Naphthyl)
carbamoyloxy]ethyl (NCE) Group.
Tetrahedron Lett. 2000, 41, 5623-5626.     pdf

Maier, M. A.; Guzaev, A. P.; and Manoharan, M. Synthesis of Chimeric Oligonucleotides Containing Phosphodiester,
Phosphorothioate, and Phosphoramidate Linkages.
Organic Lett. 2000, 2, 1819-1822.     pdf

Bhat, B.; Balow, G.; Guzaev, A.; and Manoharan, M. Synthesis of Fully Protected Nucleoside – Folic Acid Conjugated
Phosphoramidites and Their Incorporation into Antisense Oligonucleotides.
Nucleosides & Nucleotides 1999, 18,
1471-1472.

Guzaev, A.* and Manoharan, M. Synthesis of Oligonucleotide Conjugates with the aid of N-chloroacetamidohexyl
Phosphoramidite Reagent.
Nucleosides & Nucleotides 1999, 18, 1455-1456.

Guzaev, A.;* Balow, G.; and Manoharan, M. Synthesis of Chimerical Oligonucleotides Containing Internucleosidic
Phosphodiester and S-Pivaloyl Mercaptoethyl Phosphotriester Linkages.
Nucleosides & Nucleotides 1999, 18, 1391-
1392.

Guzaev, A.;* Boyode, B.; Balow, G.; Tivel, K. L.; and Manoharan, M. Use of [4,6-di-14C]-5'-DMT-thymidine
Phosphoramidite Reagent for the Radiolabeling of Synthetic Oligonucleotides.
Nucleosides & Nucleotides 1999, 18,
1389-1390.

Guzaev, A.* and Lönnberg, H. Solid Support Synthesis of Ester Linked Hydrophobic Conjugates of Oligonucleotides.
Tetrahedron 1999, 55, 9101-9116.     pdf

Wang, J.-C.; Just, G.; Guzaev, A. P.; Manoharan, M. Stereoselective Synthesis of a Cyano Alkylphosphonate by
Intramolecular Rearrangement.
J. Org. Chem. 1999, 64, 2595-2598.     pdf

Guzaev, A.* and Manoharan, M. Conjugation of Oligonucleotides via an Electrophilic Tether: N-Chloroacetamidohexyl
Phosphoramidite Reagent.
Bioorg. Med. Chem. Letters 1998, 8, 3671-3676.     pdf

Guzaev, A.;* Boyode, B.; Balow, G.; Tivel, K. L.; and Manoharan, M. Synthesis of 14C-Radiolabeled Oligonucleotides
with a Novel Phosphoramidite Reagent.
Bioorg. Med. Chem. Letters 1998, 8, 1123-1126.     pdf

Salo, H.; Guzaev, A.; and Lönnberg, H. Disulfide Tethered Solid Supports for Synthesis of Photoluminescent
Oligonucleotide Conjugates: Hydrolytic Stability and Labeling on the Support.
Bioconjugate Chem. 1998, 9, 365-
371.     
pdf

Guzaev, A.* and Lönnberg, H. Bishydroxymethylation of the Active Methylene Group of 1,3-Dicarbonyl and Related
Compounds.
Synthesis 1997, 1281-1284.     pdf

Guzaev, A.* and Lönnberg, H. A Novel Solid Support for Synthesis of 3'-Phosphorylated Chimeric Oligonucleotides
Containing Internucleosidic Methyl Phosphotriester and Methylphosphonate Linkages.
Tetrahedron Letters 1997, 38,
3989-3992.     
pdf

Guzaev, A.;* Salo, H.; Azhayev, A.; and Lönnberg, H. Synthesis of Oligonucleotide Analogues by Using
Phosphoramidite Reagents Derived from 2,2-bis(hydroxymethyl)malonates.
Coll. Czechoslovak Chem. Comm. 1996,
61, Special Issue, 226-229.

Salo, H.; Guzaev, A.; Azhayev, A.; and Lönnberg, H. Disulfide Tethered Solid Supports for Oligonucleotide Synthesis:
Preparation and a Comparative Study on the Resistance to Ammonolysis.
Coll. Czechoslovak Chem. Comm. 1996,
61, Special Issue, 110-111.

Kuusela, S.; Guzaev, A.; and Lönnberg, H. Zn2+ Promoted Hydrolysis of Oligonucleotides.
Coll. Czechoslovak Chem.
Comm
. 1996, 61, Special Issue, 30-32.

Kuusela, S.; Guzaev, A.; and Lönnberg, H. Acceleration of the Zn2+ Promoted Phosphodiester Hydrolysis of
Oligonucleotides by the 3'-Terminal Monophosphate Group: Intrastrand Participation over Several Nucleoside Units.
J. Chem. Soc. Perkin Trans. II 1996, 1895-1899.     pdf

Guzaev, A.;* Salo, H; Azhayev, A; Lönnberg, H. Novel Non-Nucleosidic Building Blocks for the Preparation of
Multilabeled Oligonucleotides.
Bioconjugate Chem. 1996, 7, 240-248.     pdf

Senchenko, V. N.; Guzaev, A. P.; Boitsova, S. E.; Maiorov, V. A.; Dudich, I. V.; Shlyapnikov, S. V.; Karpeiskii, M. Ya.
Preparation and Properties of Hybrid RNase S’ formed by S Protein and the S-S bond Conjugate of [Nle-13, Cys-20]
S-Peptide with 3'-Thiopropyl Derivative of d(T)15.
Mol. Biol. (Moscow) 1996, 30, 681-691.

Petrovskaya, L. E.; Kryukova, E. A.; Yakimov, S. A.; Wulfson, A. N.; Alibaeva, R. A.; Shingarova, L. N.; Guzaev, A. P.;
Abramov, V. M.; and Korobko, V. G. Effect of Topography of the Signal Protease Cleavage Site on Secretion of
Human Granulocite Macrophage Colony Stimulating Factor into Periplasm of Escherichia coli Cell.
Bioorg. Khim.
(Moscow)
1995, 21, 912-919. English translation: Russ. J. Bioorganic Chem., 1995, 21, 785-791.

Azhayeva, E.; Azhayev, A.; Guzaev, A.; Lönnberg, H. Selective Binding of Looped Oligonucleotides to a Single-
Stranded DNA and Its Influence on Replication in vitro.
Nucleic Acids Res. 1995, 23, 4255-4261.     pdf

Guzaev, A.;* Salo, H.; Azhayev, A.; Lönnberg, H. A New Approach for Chemical Phosphorylation of Oligonucleotides
at the 5'-Terminus.
Tetrahedron 1995, 51, 9375-9384.     pdf

Kuusela, S.; Azhayev, A.; Guzaev, A.; Lönnberg, H. The Effect of 3'-Terminal Monophosphate Group on Metal-Ion-
Promoted Hydrolysis of Phosphodiester Bonds of Short Oligonucleotides.
J. Chem. Soc. Perkin Trans. II 1995, 1197-
1202.     
pdf

Hovinen, J.; Guzaev, A.; Azhayeva, E.; Azhayev, A.; Lönnberg, H. Imidazole Tethered Oligodeoxyribonucleotides:
Synthesis and RNA Cleaving Activity.
J. Org. Chem. 1995, 60, 2205-2209.     pdf

Azhayeva, E.; Azhayev, A.; Guzaev, A.; Hovinen, J.; Lönnberg, H. Looped Oligonucleotides Form Stable Hybrid
Complexes with a Single-stranded DNA.
Nucleic Acids Res. 1995, 23, 1170-1176.     pdf

Guzaev, A.;* Hovinen, J.; Azhayev, A.; Lönnberg, H. A General Approach for the Hydroxy Group Functionalyzation of
Synthetic Oligonucleotides.
Nucleosides & Nucleotides 1995, 14, 833-837.

Hovinen, J.; Azhayev, A.; Guzaev, A.; Lönnberg, H. Synthesis of Analogues of 3'-Deoxypsicothymidine.
Nucleosides &
Nucleotides
1995, 14, 329-332.

Hovinen, J.; Guzaev, A.; Azhayev, A.; Lönnberg, H. Novel Non-Nucleosidic Phosphoramidite Building Blocks for
Versatile Functionalization of Oligonucleotides at Primary Hydroxyl Grous.
J. Chem. Soc. Perkin Trans. I 1994, 2745-
2749.     
pdf

Guzaev, A.; Azhayeva, E.; Hovinen, J.; Azhayev, A.; Lönnberg, H. Synthesis and Primer Properties of
Oligonucleotides Containing 3'-Deoxypsicothymidine Units, Labelled with Fluorescein at the 1'-Position.
Bioconjugate
Chem
. 1994, 5, 501-503.     pdf

Hovinen, J.; Guzaev, A.;* Azhayev, A.; Lönnberg, H. Novel Solid Supports for the Preparation of 3'-Derivatized
Oligonucleotides: Introduction of 3'-Alkylphosphate Tether Groups Bearing Amino, Carboxy, Carboxamido, and
Mercapto Functionalities.
Tetrahedron 1994, 50, 7203-7218.     pdf

Azhayev, A.; Guzaev, A.; Hovinen, J.; Mattinen, J.; Sillanpää, R.; Lönnberg, H. Synthesis and Properties of 3'-
Deoxypsiconucleosides: Anomeric 1-(3'-deoxy-D-erythro-2-hexulofuranosyl) thymines and 9-(3-deoxy-D-erythro-2-
hexulofuranosyl)adenines.
Synthesis 1994, 396-400.     pdf

Hovinen, J.; Azhayeva, E.; Azhayev, A.; Guzaev, A.; Lönnberg, H. Synthesis of 3'-O-(aminoalkoxymethyl)thymidine 5'-
triphosphates, Terminators of DNA Synthesis that Enable 3'-Labelling.
J. Chem. Soc. Perkin Trans. I 1994, 211-
217.     
pdf

Hovinen, J.; Guzaev, A.;* Azhayev, A.; Lönnberg, H. Synthesis of 3'-Functionalized Oligonucleotides on a Single Solid
Support.
Tetrahedron Lett. 1993, 34, 8169-8172.     pdf

Azhayev, A.; Gouzaev, A.; Hovinen, J.; Azhayeva, E.; Lönnberg, H. Analogues of Oligonucleotides Containing 3'-
Deoxy-b-D-psicothymidine.
Tetrahedron Lett. 1993, 34, 6435-6438.     pdf

Hovinen, J.; Gouzaev, A. P.; Azhayev, A. V.; Lönnberg, H. A New Method to Prepare 3'-Modified Oligonucleotides.
Tetrahedron Lett. 1993, 34, 5163-5166.     pdf

Guzaev, A. P. An Efficient Synthesis of N2-isobutyryl-O6-[2-(4-nitrophenyl)ethyl]-5'-dimethoxytrityl-2'-
deoxyguanosine.
Nucleosides & Nucleotides 1992, 11, 1463-1466.

Hakala, H.; Oivanen, M.; Saloniemi, E.; Gouzaev, A.; Lönnberg, H. Acid-Catalyzed Depurination of di, tri- and
Polydeoxyribonucleotides: Effect of Molecular Environment on the Cleavage of Adenine Residue.
J. Phys. Org.
Chem
. 1992, 5, 824-828.     pdf

Karlyshev, A. V.; Galyov, E. E.; Smirnov, O. Yu.; Guzayev, A. P.; Abramov, V. M.; Zav'yalov, V. P. A New Gene of the
f1 Operon of Y.pestis Involved in the Capsule Biogenesis.
FEBS Letters 1991, 297, 7780.     pdf

Guzaev, A. P. An Efficient Synthesis of 3'-Mercaptoalkylated Oligodeoxyribonucleotides on the Universal Solid
Support.
Nucleic Acids Res. Symposium Series 1991, No 24, 236.

Moskovkin, A. S.; Guzaev, A. P.; Miroshnichenko, I. V.; Botnikov, M. Ya.; Unkovskii, B. V. Mass Spectrometric Study of
Products Resulting from Intramolecular Cyclization of 1,3-Amido Alcohols. 5,6-Dihydro-4H-1,3-oxazines and 2-
Oxazolines.
Khim. Geterotsikl. Soedin. 1988, 1539-1543 (in russian); CA 111: 96485w; Chem. Heterocycl.
Compounds
1988, 24, 1277-1281 (Engl. Translation).
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